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Maximal brain volume (ICA) accounted for 6.2% of the variance in g in old age, whereas atrophy accounted for < 1%.
Intracranial area (ICA) (a measure of maximal brain volume) was measured by manually tracing the inner table of the cranial vault on the midline slice of the sagittal localizer [ 13].
Statistically significant associations between brain areas and specific cognitive abilities became non-significant when corrected for maximal brain volume (estimated using ICA), i.e. there were no statistically significant associations between atrophy and cognitive ability.
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Studies of the structural basis of cognitive ageing therefore need to consider both maximal and current brain volume; both prior (typically using a valid estimate) and current cognitive abilities; and both specific and general cognitive abilities.
(p. 736) One study that investigated the relationship between brain size and cognition in older adults measured intracranial area (ICA) – an estimate of maximal brain size [ 13] – and several regional brain volumes in 97 unmedicated healthy older men (mean age 67.8, SD 1.3 years).
However, this method has some weaknesses: the nonlinear relationship between brain volumes and intracranial volume [ 44] and the fact that the maximal brain size seems to be an important predictor of cognition in old age, independent of brain pathology [ 45].
Another recent study also stated that normalizing volumes to ICV is inadequate due to the fact that the maximal brain size seems to be an important predictor of cognition in old age, independent of brain pathology (Farias et al. 2011).
Head circumference correlates about 0.60 with MRI brain volume (Rushton & Ankney 2007) and was measured using a stretchless tape along the maximal plane of the skull just above the ear.
To calculate the percentage of [11C](R -PK11195 injected that was pR -PK11195the brainjectede that of maximal radioactivity, the radioactivity concentration in the ROI for the wasle brain was multipresenty the estinathe average brain volume (1,250 mL), divided by the ratioactheitimenjected and multiplied by 100 tofobtain the percentage of injected radioactivity.
We hypothesised that: (a) current brain volume would be associated with current cognitive ability, (b) this association would be attenuated when corrected for maximal (prior) brain volume and (c) the association would be due to the relationship between general cognitive ability and overall brain size, not specific cognitive domains and brain regions.
The researchers also noted brain volume.
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