Sentence examples for maturity of neurons from inspiring English sources

Thus, for the current study it was important to determine the maturity of neurons within the microfluidic culture chambers.

A recurring practical question about the use of these systems for modelling neurological disease is that of the functional maturity of neurons generated in vitro from PSCs.

Co-culture of cESC-derived neurons with primary canine fetal cells on canine astrocytes was used to test functional maturity of putative neurons.

These data suggest that spontaneous activity depends upon the maturity of the neurons in culture.

To examine the functional maturity of our hNPs derived neurons we performed electrophysiological recordings using the whole-cell patch clamp technique and intracellular calcium measurements using the FURA-2AM assay.

Electrophysiological techniques are not the only approaches to investigate the phenotype and maturity of stem cell-derived neurons.

A lot of researches confirmed that electrical activity and potential depolarization could protect the synaptic connection which was established in the embryo and participated in the neural activity of neurons and promoted its maturity by selecting mechanism [ 24, 25].

Counting of double-positive cells for BrdU and NeuN showed no significant differences between the HGPS and wild-type animals (P = 0.65; Fig.  6I), suggesting that the fraction of neurons that have reached maturity was similar in both populations.

Thus, MAP2 staining could be used as reference baseline for the maturity of both rat and mouse neurons fixed after 14 days in culture (Additional file 6: Figure S2) [ 51– 51].

For neuronal cultures, informative measurements include the proportion of neurons in culture, the subtypes of neurons present, and the degree of neuronal maturity, which can be estimated using electrophysiological methods.

These data suggest that knockdown of UBE3A alone can cause a depolarization of RMP independent of neuron maturity.