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Look to the CMO to embrace the mature methodologies that matter, and meld these with what technology and data now make possible.
Powerful genetic tools and mature methodologies such as forward genetic screens, generation of transgenic animals and RNA interference (RNAi) in a tissue-specific fashion have been developed that have greatly facilitated research in C. elegans.
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Whereas top-down MS of proteins is currently growing into a mature methodology, for which electron capture dissociation (ECD) and collisionally activated dissociation (CAD) of [ M+ n H] n + ions from electrospray ionization (ESI) provide complementary sequence information, 4 top-down MS of RNA is far from being established.
As inventories have matured, methodology increasingly is both influenced and vetted by the international scientific community, a process which ensures rigour and provides documentation for the user community.
Despite the fact that this brought sufficient technology for a mature engineering methodology, little use is made of it in current practice, and developing 'intelligent' software is not much different today from what it was at the beginning of the 1980s.
System-level design issues are gaining increasing attention, as behavioral synthesis tools and methodologies mature.
However, there currently is no mature and specialized methodology to evaluate the accuracy of input output (IO) data.
While the literature does present several mature pattern-driven security methodologies with either a general or a highly specific system applicability, there are currently no (pattern-driven) security methodologies specifically designed for general distributed systems.
While software engineering methodologies have matured to handle non-functional requirements such as usability, what has not been investigated fully is the emotional needs of people.
Even as the methodology matured, there remained a challenge to integrate it into the regulatory process.
As the methodology matured, a general theoretical framework was developed that supports the consistent analysis of 'false-recent' results [ 5].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com