Few randomized trials are available, with mature data.
Numerous new agents are specifically addressing resistance mechanisms; mature data are related to the T790M mutation and MET pathway activation.
The board of the radiation oncology society, the American Society for Therapeutic Radiology and Oncology, or Astro, has called CyberKnife promising, but raised questions this year about the evidence supporting its use in prostate cancer, saying "there is not sufficient or mature data to demonstrate equivalency to existing standard treatment modalities".
The bar for clinical benefit should be raised for drug registration, which should require publication and review of mature data from RCTs, post-marketing health outcome studies, and value-based pricing.
To report the mature data of a prospective Phase II trial designed to evaluate the efficacy of an epidermal growth factor receptor inhibitor cetuximab (CTX) added to the concurrent therapy of weekly paclitaxel/carboplatin (PC) and daily radiation therapy (RT).
Rather than the usual practice of increasing sample size with a less positive interim outcome, here we propose maintaining sample size with such a result and wait for fully mature data.
While we have a mature data infrastructure including a centralized data and analytics team, a standalone virtual data warehouse linking all data silos, and strict enterprise-wide data governance, we reasoned that the best way forward would be to collaborate with other institutions that had additional and complementary data capabilities and expertise.
Firms within these industries have also been most likely to develop mature data management processes and practices.
But algorithms mature, data becomes more ubiquitous and finding edges like Pandora's strength in discovery becomes easier and easier as time goes on.
The exploration of CAR-T cells targeting CD19 for patients with CLL is earlier than B-ALL; however, less mature data have been reported.
