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Since hemozoin appeared to have a significant effect on the survival of erythroid precursors as well as on their maturation we determined the role of hemozoin in the induction of apoptosis in erythroid cells.
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We determined phenotypic maturation of monocytes, myeloid (m) and plasmacytoid (p) DC and production of cytokines in the culture supernatants.
Because miR-155 is strongly induced in DCs upon maturation, we sought to determine whether its expression holds immunological significance.
To define the mechanisms by which Pak2 regulates thymocyte development and maturation, we sought to determine Pak2's function in TCR-induced signaling events.
To address the mechanism underlying the observed erythroblast maturation defect, we first determined whether cell cycle and apoptosis was normal in Mtf2−/− erythroblasts.
We broadly classified SP P14-CD8+ thymocytes based on their maturation status determined by CD24 and Qa2 expression.
Therefore, in this study, we investigated whether the timing of the appearance or course of the deviation from normal brain maturation, as determined using a machine learning algorithm trained on structural MRI data to estimate age, is potentially relevant to the early versus late neurodevelopmental framework among CHR individuals.
To assess whether birth at <26 weeks gestation is an important predictor of brain microstructure <span class="lh">maturation as determined by using diffusion tensor imaging.
The experiments were based on freshly isolated porcine OCC cultures in which the consequences of PR and COX-2 inhibition on the final processes of oocyte maturation were determined.
We here show that DCs that lack P-gp function, either genetically or pharmacologically, have decreased levels of maturation, as determined by the expression of co-stimulatory molecules like CD40, CD80, CD86 and MHC class II antigens on CD11c+ DCs.
The effects of Hdac3 depletion on skeletal maturation were determined by crossing Hdac3fl/− mice [11], [31] with mice expressing Cre recombinase from the osterix (Osx) promoter [30].
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