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The evidence that BMP-4 plays a central role in DC maturation was provided by using BMP antagonist Noggin, which reverted the antigen presentation capacity of naive PLP-pulsed DCs co-cultured with NPCs in vitro.
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Further evidence indicating that asparaginyl endopeptidases play a role in wheat storage protein maturation is provided by the comparison of the N-terminal sequences of different LMW-GS.
In our study we have used apoptotic cells, and the requirement for DC maturation signals was provided by a standardized maturation cocktail.
Evidence was provided for the further maturation of these cells in vivo.
Induction of immunity is achieved when a maturation signal is provided as has been demonstrated in the murine system.
Further details about using a logistic regression approach for estimating maturation reaction norms are provided by Heino et al. (2002).
Support for this idea is provided by the inhibition of germinal vesicle breakdown (GVBD), which is the hallmark of meiotic maturation, by pertussis toxin [2] [4].
Analyses of mRNA abundance during seed development, maturation, and beyond are providing clues as to the global gene expression that determines final seed structure and composition in Arabidopsis [ 8- 12], Medicago truncatula [ 13- 15], Brassica napus [ 16, 17], rice [ 18, 19], barley [ 20], and soybean [ 21].
Second, disruptive selection is more likely in stocks in which the selective pressure for early maturation is naturally strong, provided life-history tradeoffs are sufficiently consequential.
The extensive tubulation during macropinosome maturation is considered to provide a potential mechanism for rapid membrane and cargo protein recycling back to the plasma membrane for subsequent macropinocytic events.
Maturation was assumed to occur when an individual had reached 66% of its L∞, a threshold (Fig. 1) that has been found to provide a good proxy of the timing and the size at maturation (Jensen 1997).
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