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In general, the process of autophagy begins by double-membrane initiation, followed by cargo recognition, and fusion with lysosomes (autophagosome maturation) that results in cargo degradation.
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Significantly, although both pathways activate STAT3, they modulate DCs maturation in a different manner that results in disparate phenotypic outcomes.
Together, results delineate a process of structural network maturation that supports executive function in youth.
We developed an exceptionally accessible virus system for the study of the activators of maturation and the downstream consequences that result in particle stability and infectivity.
Moreover, in adolescent AN, starvation-induced hormonal deficiencies may lead to impairments in the maturation of certain brain regions that result in deficits in neuropsychological functioning [ 15- 17].
The major abnormal maturation of meat that results in whole carcass condemnation is dark, firm, dry meat (DFD).
It is known that maturation results (in some cases) in defunctionalization of susceptible labdanoid monomers,[6] but the primary maturation pathway of these materials involves changes in the nature and abundance of unsaturated structures.
As the final step of myogenesis, newly formed multinuclear myotubes will undergo further maturation processes that eventually result in functional myofibers with specialized structures such as neuromuscular junctions (NMJs).
We recently observed that maturation also results in a dramatic reprogramming of the glycosylation machinery, especially with regard to sialylation [5].
Migration of iDC to T cell area of secondary lymphoid tissues after virus uptake is associated to a maturation process, that allows the resulting mature DC (mDC) to prime an antigen-specific response [11].
DOI: http://dx.doi.org/10.7554/eLife.04234.011 To confirm that the ∼30 kDa fragment we observed was identical to the polypeptide that results from proteolytic maturation in vivo, we examined the assembly of a non-cleavable version of EspP(46+β).
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