These findings led to the idea that mTECs undergo a linear differentiation process, from mTEC progenitors down to terminally differentiated mTECs, recently defined by a final post-Aire stage of maturation that is controlled by expression of Aire itself 37, 40.
During normal development, RUNX2 is a principal component of a genetic regulatory pathway that controls osteoblast maturation and bone formation in vivo [ 36- 40].
Moreover, curcumin can decrease the levels of Aurora A, a mitotic kinase that controls centrosome maturation and spindle formation (10).
The pathobiology of osteolytic bone metastases has been widely studied, revealing a central role for the RANKL-RANK system that controls osteoclast maturation [ 7].
Mechanistically, WDR62 physically and genetically interacts with AURORA A [ 60], a serine/threonine protein kinase that controls centrosome maturation, spindle formation, and mitotic progression.
Cbln1 is a secretory protein necessary for dendritic spine integrity and maturation (Kusnoor et al, 2010), and Tln2 is a critical molecule that controls spine morphology and maturation through the actin network (Terry-Lorenzo et al, 2005).
We propose that postsynaptic Lola functions as a transcription factor that controls synapse formation and/or maturation by regulating the expression of multiple synaptic components.
However, control of the CM maturation that is subsequently required to generate adult myocytes remains elusive.
They tracked gene activity over the 3-day maturation period of a TH17 cell and revealed the molecular circuit that controls the process.
Abscisic acid (ABA) is a plant hormone that controls seed germination, protective responses to various abiotic stresses and seed maturation.
