We then analyzed the maturation status of NK cells after syngeneic HSCT, as their maturity is deeply related to the function of NK cells 23.
Since cells were fully matured by overnight incubation in the presence of TNFα, INFγ and PGE2 the maturation status of the DCs did not change after electroporation with the RNAs (Data not shown).
The maturation status of DCs is relatively important for them whether to induce immune tolerance or to initiate immune response.
(G) In normal condition, Sdo1p, as a member of a conformational signal relay system, probes the maturation status of the ribosomal P-site, and passes the signal to Efl1p to release Tif6p from the nearly mature 60S subunit.
Altogether, these results support our hypothesis that Sdo1p is a dynamic probe of the maturation status of the 60S subunit, and the inter-domain flexibility of Sdo1p/SBDS is essential for its function.
Developing an inducible expression system capable of shutting down some progenitor genes' expression at certain time points would be crucial for controlling the switch between the proliferation and maturation status of these Best1::GFP+ cells.
The maturation status of T cells is also an important issue.
In general, the maturation status of DCs is a key determinant of how the immune response will evolve [8], [9].
