Your English writing platform
Discover LudwigSuggestions(5)
Exact(6)
There are two aspects of paedomorphosis: acceleration of sexual maturation relative to the rest of development (progenesis) and retardation of bodily development with respect to the onset of reproductive activity (neoteny).
mCherry maturation relative to GFP has been shown to be inefficient using Fluorescence Cross-Correlation Spectroscopy, which revealed that only 45% of tandem EGFP-mCherry molecules contained an active mCherry.
For example, among the 18 genes significantly enriched in the category "endosome membrane" (Table 3), up-regulation of Cftr and Lamp1 at both the mRNA and protein levels (maturation relative to secretory) have been shown previously [ 13, 40, 41].
Two other examples listed in Table 3, Slc26a7 and Tfrc, have also been confirmed as being up-regulated at both the mRNA and protein levels (maturation relative to secretory) by our group (data not included).
For example, the highly invasive zebra mussel D. polymorpha, which originates from the unstable Ponto-Caspian basin, has high fecundity (Sprung 1991) and rapid maturation relative to other bivalve species, such as the unionid mussels that they are often driving to local extinctions (Mackie 1991).
However, upon IP via the FLAG tag of Pen-2, N8A, P27A, and N33A all displayed unaltered levels of γ-secretase maturation relative to that of wt Pen-2, but I53A showed <40% wt levels of PS1-CTF associated with Pen-2, suggesting an impaired complex stability.
Similar(54)
We identified 59 miRNAs that were differentially expressed at the maturation stage relative to the secretory stage of enamel development (False Discovery Rate (FDR) < 0.05, fold change (FC) ≥ 1.8).
A total of 8,492 unique candidate target genes were predicted to be regulated by the 39 up-regulated (maturation- relative to secretory-stage) miRNAs.
Likewise, 6,518 unique candidate target genes were predicted to be regulated by the 20 down-regulated (maturation- relative to secretory-stage) miRNAs.
To place our observations in perspective, we compared the list of predicted gene targets of stably expressed miRNAs with the list of differentially expressed mRNAs (maturation- relative to secretory-stage).
Among these 59 stage-specific miRNAs, 39 were up-regulated during maturation stage (relative to secretory stage) while 20 were down-regulated.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com