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Monocyte-derived DCs can be generated by monocyte cultivation with GM-CSF and IL-4 [16], [16] or IL-13 [17] in vitro, and this makes it possible to generate large quantities of DCs providing a model to investigate the effect of self or environmental agents on the differentiation and maturation pathways of DCs.
Comparing the maturation pathways of mRNAs and lncRNAs revealed that transcript fate is largely determined during 3′ end formation.
After arising from a common progenitor in the thymus, the maturation pathways of γδ and αβ T cells diverge.
Morphological and molecular data speak in favour of a separation of the maturation pathways of SN and NSN oocytes and possibly a distinct fate within the ovary.
In regards to the maturation pathways of miRNAs, the prediction of genomic precursors revealed some interesting aspects of the miRNAs within this study.
Accordingly, a hypothetical model shown in Figure 8 depicts the maturation pathways of two fusion proteins and their possible distinct actions on the clearance of bacterial DNA and apoptotic DNA.
Similar(52)
Therefore, the alternative strategy uses the endogenous miRNA maturation pathway of a cell to ectopically produce mature miRNAs from plasmids containing a primary microRNA transcript.
Cellular cryo-electron tomography and thin-section EM studies uncovered the assembly and maturation pathway of STIV and revealed dramatic cellular ultra-structure changes upon infection.
It is known that maturation results (in some cases) in defunctionalization of susceptible labdanoid monomers,[6] but the primary maturation pathway of these materials involves changes in the nature and abundance of unsaturated structures.
Therefore, we conclude that the localisation of U1 snRNP proteins in these two compartments is specific and most likely reflects maturation pathway of U1 snRNP in vivo.
The affinity maturation pathway of CH58 described by Nicely and colleagues is a clear example of the antibody precursor paratope being largely pre-configured, and gaining in affinity from few mutations that improve off-rates.
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