The differentiation and maturation of DCs require more synthetic materials and energy production, with enhancement of the whole cellular or subcellular metabolism and function.
We demonstrate that maturation of spores requires VosA, which triggers an active buildup of trehalose and assists in the proper formation of the conidial wall.
The development of the follicle and the maturation of oocyte require orchestrated communication between oocytes and GCs at all stages of early folliculogenesis.
The detailed mechanism by which cathepsin K regulates TLR9 signaling remains elusive, but it has been reported that functional maturation of TLR9 requires its proteolytic cleavage [ 86, 87], to which cathepsin K might contribute.
Production and maturation of miRNAs require a set of proteins collectively known as the miRNA biogenesis machinery and it is now established that alterations in this machinery can generate changes in miRNA expression and contribute thus in the development and progression of cancer.
The maturation of INPs requires Numb, the NHL family protein Brain tumor (Brat), the transcription factor Earmuff (Erm), as well as the BAP and Histone deacetylase 3 (HDAchromatinatin remodeling complexes (Bowman et al., 2008; Weng et al., 2010; Eroglu et al., 2014; Koe et al., 2014).
The strongest indication for aryl sulfatase activity is probably the existence of sulfatase maturation enzymes, required for the post-translational modification of a cysteine or serine into the catalytically active Cα-formylglycine aldehyde, or the corresponding catalytically active hydrate (Fig. 1).
Future studies to investigate the phosphorylation state of HBV capsids at different stages of genome maturation are required to resolve this issue.
LAMP1 is an abundant lysosomal membrane protein that is both delivered to phagosomes during their maturation and required for fusion of lysosomes with phagosomes [39] and autophagosomes [40].
It ensures that proerythroblasts properly expand and that RBCs are long-lived, but its most critical roles are to ensure that the output of definitive erythropoiesis is not delayed or decreased by the additional steps of cell maturation required for erythroblast condensation and enucleation.
