Sentence examples for maturation of focal from inspiring English sources
Subsequent activation of RhoA induces the maturation of focal complexes to focal adhesions, assembly of stress fibers, and cell locomotion [50].
It is well established that the maturation of focal adhesions is promoted by applied tension, suggesting a stretch-activated sensor mechanism [45] [48].
The ability of integrins to bind matrix ligands and to transduce information of what they have encountered is controlled by upstream (inside-out) receptor activation, formation and maturation of focal complexes and adhesions, and downstream (outside-in) signal transduction, and each of these processes has been functionally linked to the actin cytoskeleton [29], [32] [34].
Dia may be involved in maturation of focal adhesions as a mechano-sensor.
Moreover, FAK binds to p190RhoGEF which leads to the activation of Rho and maturation of focal adhesions in association with tumor migration [ 54].
Thus our results suggest that the knockdown of α8 in HIEC impaired the maturation of focal contacts at the late FX stage.
Furthermore, ECM-induced mechanical stimulation brings about maturation of existing focal adhesions and formation of new focal adhesions, with a consequent increase in the strength and the rigidity of the connection between the integrins and the cytoskeleton.
We find the last possibility especially intriguing, as it would suggest a peculiar symmetry between the initiation and maturation of the focal adhesions.
Moreover, tension-mediated maturation of terminal focal adhesions leads to inhibition of vectorial actin polymerization, which is at least partially mediated by phosphorylation of VASP.
But at around 5 pN, R3 unfolds disrupting the RIAM binding sites resulting in a transition to vinculin:talin complexes which drives the maturation of nascent adhesions into focal adhesions.
Conditional Foxc1 mutants do not have widespread defects in BBB maturation, though focal breakdown of BBB integrity is observed in large, dysplastic vessels.
