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Although KIRs control the reactivity of mature NK cells, their expression also influences the functional maturation of developing NK cells.
In particular, we present evidence that miR-34a overexpression results in: (i) increased proliferation of precursor cells; (ii) inhibition of neurite branching and delayed maturation of developing neuronal cells; (iii) altered physiological features of mature neurons; (iv) improvement in behavioural outcomes.
For example, PV interneurons play a critical role in the maturation of developing local circuits in the visual cortex47.
We discuss how mechanisms of chromatin regulation help to orchestrate the transcriptional programs that underlie the maturation of developing neurons and the plasticity of adult neurons.
Then, dental mesenchyme generates signals promoting the maturation of developing ameloblasts.
Contact with secondary lymphoid organs is vital for the completion of post-thymic maturation of developing SP thymocytes [1].
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The surrounding stromal micro-environment, the presence of appropriate growth factors, as well as their ability to respond to them, are all crucial players in the final maturation steps of developing B cells.
It has been shown that lipid and starch deposition, which are associated with the progression of maturation in cotyledons of developing soybean embryos, begins in the interior cells of the organ and progresses to the periphery [ 35].
Important among these are several vitamins such as riboflavin, vitamin B12, and folic acid, necessary for the maturation of the developing red cell; and vitamin B6 (pyridoxine), required for the synthesis of hemoglobin.
Bacterial products are also crucial for the normal immune system development; for example, a single bacterial polysaccharide (PSA) from a commensal bacterium Bacteroides fragilis was shown is capable of directing the complete cellular and physical maturation of the developing immune system [15].
Mazmanian et al. (2005) [14] for example demonstrated that the Bacteroides fragilis polysaccharide directs the cellular and physical maturation of the developing immune system of the mouse host, including correcting systemic T cell deficiencies and T(h 1/T(h)2 imbalances and directing lymphoid organogenesis.
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