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Such widespread hypometabolic changes related to the maturation of cortical and subcortical structures may complicate the interpretation of SPM results in children when compared to adults (is a given hypometabolism pathological or physiological?) and may decrease the sensitivity of detection of hypometabolic areas using SPM.
Apparently, the impaired maturation of cortical cerebellar (and cerebral) dendritic spines also prevents a proper prepulse inhibition in mice [54].
In the case of layer VI pyramidal neurons, the timing of the sex differences in nicotinic currents suggests that they may contribute to sex differences in the refinement and maturation of cortical projections to the inhibitory thalamic reticular neurons and excitatory thalamic projection neurons [8], [47], [48], [49].
The development of language depends on auditory skills and maturation of cortical functions (memory, attention, and intellectual abilities) [ 13, 14].
Delay in the maturation of cortical inhibition of detrusor contractions is considered among the pathophysiological theories [ 2].
These results demonstrate that Lhx6 plays an important role in the maturation of cortical interneurons and the formation of inhibitory circuits in the mammalian cortex.
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Consequently, a developmental cascade in time may be paralleled by a maturation hierarchy of cortical visual areas, where the maturation of each visual function or cortical visual area may rely on the maturation of the ones preceding it.
In order to demonstrate that avalanche dynamics also capture spatiotemporal activity in L2/3 PNs in vitro, we conducted studies in GECI-expressing cortical slices, co-cultured with VTA to ensure proper maturation of superficial cortical layers (Gireesh and Plenz, 2008).
Little is known about the critical period during which the dietary supply of long-chain polyunsaturated fatty acids (LCPUFAs) may influence the maturation of visual cortical function in term infants.
Ultimately, the pattern of folding forces is determined by the intrinsic architecture of the cortex, and the size, relative position and temporal maturation of distinct cortical areas.
Although recent studies indicated that excitatory action of GABA is necessary for the proper maturation of the cortical neurons (Hubner et al. 2001; Stein et al. 2004; Cancedda et al. 2007), there is limited information about the cortical distribution of KCC2 during early postnatal development (Takayama and Inoue 2010).
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