Sentence examples for maturation of client from inspiring English sources

The co-chaperone complex R2TP assists Hsp90 in the folding and maturation of client proteins such as phosphatidylinositol-3-kinase-like kinases.

Hsp90 is a homodimeric ATPase that is essential in eukaryotes for the maturation of client proteins frequently involved in signal transduction, including many kinases and nuclear steroid hormone receptors.

Hsp90 forms defined binary or ternary complexes with cochaperones to facilitate the maturation of client proteins (reviewed in Prodromou, 2012).

The cochaperone p23 associates with HSP90 late in the chaperone cycle, facilitating the maturation of client proteins [ 38].

It assists in protein folding and quality control, maturation of client proteins, and protein trafficking among subcellular compartments.

The molecular chaperone Hsp90 requires the assistance of immunophilins, co-chaperones, and partner proteins for the conformational maturation of client proteins.

With the coordinated assistance of Hsp70 and a range of co-chaperones in dynamic protein heterocomplexes, the final maturation of the client protein takes place.

However, the biochemical function of HSP90 to promote the maturation of metastable client proteins is conserved in plants, as illustrated by the fact that obligately HSP90-dependent mammalian steroid hormone receptors are functional in the plant cytoplasm, even though plants lack any homologous receptors [13].

In either case, Hsp90α may affect maturation of the client protein, Rac1, which is critical for cell migration.

The maturation of ER client proteins entails the chaperone assisted folding of nascent chains and assembly of functional complexes.

Hsp90 is an essential molecular chaperone required for the maintenance, activation or maturation of specific client proteins.