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According to our results, brain maturation might be impaired at much younger age stages preceding beta-amyloid deposition.

Thus, a mechanism by which the lack of Jak3 could negatively affect their maturation might be through a deficiency in the CCR7 signalling pathway.

We hypothesized that both high uptake and maturation might be achieved by combining prolonged R848 incubation (24 h) followed by the addition of CC.

Plastic decreases in size at maturation might be theoretically observed in species with positively-sloped PMRNs; however, almost all PMRNs calculated to-date exhibit negative slopes (Heino and Dieckmann 2008).

Moreover, as the differentiation to terminal effector cells is related to increased cytolytic potential of CD8+ T cells, we hypothesize that the extent of maturation might be due to an effective antitumor response [ 18].

As some preterm infants could exhibit IUGR, which can negatively affect neurobehavioural maturation [ 11], it is possible that this negative maturation might be related to the increased F0 of spontaneous cries in preterm infants.

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These results suggested that in the absence of Jak3, their maturation process might be compromised.

Finally, changes in maturation thresholds might be the result of phenotypic plasticity induced by environmental change.

Under these conditions, genetic variation in maturation thresholds might be maintained, thereby allowing more rapid responses to changes in selection.

To enhance DC maturation DC might be transfected with RNA encoding constitutively active TLRs or RNAs encoding co-stimulatory molecules, like CD70 and CD40L, can be introduced [ 67].

Such a condition for the maturation pathway might be the results of adaptive evolution for coping with the complicated cellular process in various eukaryotic cells.

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