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Nascent FAs that are assembled at cell front undergo either rapid turnover or maturation in response to contractile forces21.
Many insights into the mechanisms that control the process of immune cell development and maturation in response to infection come from the analysis of various gene-deficient mice that lack some or all hallmark features of lymphoid tissues.
Starfish oocytes from which the vitelline coat was removed by the treatment with actinase E or trypsin still undergo meiotic maturation in response to 1-MA [20], [21].
Using Stat5-Tg mice, we have demonstrated evidence indicating that Jak2/STAT5 is indispensable for DC development and maturation in response to inflammatory stimulation.
Together, PYCARD, NLRP3, and caspase-1 are essential for macrophage IL-1β maturation in response to a broad range of stimuli including bacteria [13], [14] and viruses [15], [16], [17], [18].
The concept of accelerated lung maturation in response to stress was initially proposed in 1980s [ 16].
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Our findings demonstrate that DCs that have endocytosed donor apoptotic cells in vivo not only retain a low ratio of co-stimulatory: inhibitory signals but also resist ex vivo-maturation in response to DC-activating signals.
Expression analysis during seed development and under dehydration conditions suggested a role for HvDME in endosperm development, seed maturation, and in response to drought.
The endoplasmic reticulum (ER) is responsible for protein folding and maturation and in response to an overload of mis/unfolded proteins, due to increased demands for protein synthesis, becomes overactivated/stressed (Hotamisligil, 2010).
DCs in the periphery capture and process antigens in their immature state followed by a maturation process in response to a spectrum of stimuli, allowing them to induce both innate and adaptive responses [1].
TCM pretreatment of MDDCs also suppressed the upregulation of maturation markers in response to LPS.
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