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Overall, our results strongly supported the work of Ponton and colleagues [7], who argued that auditory maturation could not be regarded as a unitary process, because different pathways mature at different rates.

Work upending the assumption that a cell's differentiation and maturation could not be reversed netted John Gurdon and Shinya Yamanaka this year's Nobel Prize in physiology or medicine.

Schizont maturation could not be performed with P. yoelii parasites as their schizonts rupture in vitro.

However, the low expression of CD31 indicates that complete maturation could not be achieved during the 3-week exposure to both differentiating media.

Similar(55)

The finding that the maturation rate could not be restored by the reintroduction of a single procyclin gene into the null mutant might be due to a requirement for multiple procyclin isoforms, in order for the parasite to migrate efficiently, or for appropriately regulated expression.

Our previous study revealed that inhibition of lysosomal cysteine cathepsins in murine fibroblasts leads to accumulation of a processing intermediate, but the proteinases involved in this maturation event could not be identified [10].

As previously described (Ozawa et al, 2004), aberrant structures induced by high VEGF were not covered by pericytes, but rather by NG2-negative/α-SMA-positive smooth muscle cells (Fig 1A), which have a different biological function, providing structural support but not regulatory signals to the endothelium, and therefore their maturation index could not be quantified.

On the other hand, the bundles that were grouped together should not be considered as bundles with identical maturation, but rather as bundles for which maturational relationships could not be revealed using the proposed approach and the available data.

The observed deficit in MNCV and SNCV in Ins2Akita/+ mice does not seem to reflect a delay of PNS maturation since we could not detect any differences in either myelin thickness or axonal size in three month old affected animals and our microarray data does not reveal any changes in the expression of genes involved in either Schwann cell or neuronal maturation or function (see discussion below).

We suggest that activity patterns were developed after maturation as we could not see them in young animals but in adults.

Antibody maturation measured by AI could not be followed past 90 days because of the study design but additional studies with longer follow-up durations are ongoing.

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