Improper GNP maturation can result in defective foliation, which is associated with defects in motor coordination [6], [7], or in medulloblastoma, the most common childhood brain tumor [8].
Disruption of cerebellar granular neuronal precursor (GNP) maturation can result in defects in motor coordination and learning, or in medulloblastoma, the most common childhood brain tumor.
Therefore, exposure to excess glucocorticoids in utero alters fetal organ growth and maturation patterns, which can result in adverse consequences in later life.
More generally, the memory traces of the fetus' auditory environment in which early maturation of the auditory system occurs can result in the infants' differential responding to specific stimuli.
The interaction between antigen-presenting cells (APCs), like dendritic cells and macrophages, and T cells is characterized by a bidirectional exchange of signals that can result in activation and maturation of effector T lymphocytes [ 24].
Another recent theoretical analysis examining the consequences of fisheries on stock populations suggests that common fishing policies can result in disruptive selection for maturation strategies (Landi et al. 2015).
Additionally, the modalities used to induce MoDC maturation differ between the conducted studies and ours, which can result in functional differences.
We hypothesize that maturation of other compensatory steroidogenic enzymes or cofactors during puberty in patients with NR5A1 mutations can result in significant testosterone production in some cases.
Increased levels of complex glycosylated CFTR can result from increased stability on the plasma membrane (longer half-life) or improved maturation at the ER membrane or both.
Lead exposures either in utero, during infancy, or during childhood can result in delays or impairment of neurological development, neurobehavioral deficits, low birth weight and low gestational age, growth retardation, and delay maturation in girls [ 29, 45, 51].
Activation of TLRs can result in the activation of caspase 1 and caspase 8 (Maelfait et al., 2008; Shaw et al., 2008) by the inflammasome complex, which induces the maturation of the pro-inflammatory cytokines IL-1β and IL-18.
