Conceptually, this will require the development and refinement of models of adolescent brain development that address specific aspects of pubertal maturation (e.g. specific hormones) that are causally linked to specific aspects of brain and behavioral changes.
The present findings give further indication that the efferent systems of the bv/bv mutant inner ear are independent of the afferent systems in many aspects including development, maturation as well as degeneration.
DCX has been associated with neuronal differentiation and functionally linked to cell migration and other aspects of maturation, including dendritogenesis and synaptogenesis.
Repair of full thickness JSDs involves coordination of patterning and tissue maturation that recapitulates some aspects of embryonic skeletal development [ 6], thereby requiring morphogenetic signaling.
Sexual maturation is a critical aspect of reproduction and its timing has dramatic effects on most aspects of life-history (Roff et al. 2002).
These phenomena play a critical role in all aspects of tissue maturation, from development to differentiation, and play an active role throughout the life of an organism (Engler et al., 2006; Griffith and Swartz, 2006; Swartz and Fleury, 2007).
One important aspect of maturation is the movement of WPBs to the cell periphery.
Regardless of the precise mode by which membrane transport occurs, for example vesicle mediated or compartmental maturation models, a crucial aspect of the membrane trafficking process is how specificity of membrane fusion is determined.
An important aspect of maturation of tissue DC is up-regulation of CCR7 and for mucosal DC to function in vivo, they have to migrate to the draining MLN in a CCR7-dependent manner 5. Around 40% of LP DC expressed CCR7 when cultured in medium for 8 h and this was increased substantially by all the TLR ligands examined, with 70 80% becoming CCR7+ (Fig. 6A and B).
The developing fetus and young children are disproportionately affected by methyl mercury exposure, because many aspects of development, particularly brain maturation, can be disturbed by the presence of methyl mercury.
