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Directional cell migration requires continuous formation, maturation, and turnover of FAs at the leading edge.
RNase-controlled RNA degradation is a determining factor in the control of gene expression, maturation and turnover, which are further associated with the progression of cancers and infectious diseases.
The complexity of CFTR maturation and turnover requires the use of cellular models that closely recapitulate the specific properties of the clinically most affected organs.
Furthermore, the complexity of the mutant CFTR maturation and turnover kinetics requires the use of advanced cellular models that closely recapitulate the properties of the most affected organs (lung, bile duct, pancreas, and intestine).
RNase II contains a highly processive 3'→5' exoribonuclease activity, and eukaryotic Dis3 homologs (Rrp44 in budding yeast) were identified as a component of the exosome that is required for RNA maturation and turnover in both the nucleus and cytoplasm [8] [10].
This finding implies that more Treg in the circulation of patients with SCCHN than in NC are terminally differentiated and are undergoing rapid maturation and turnover.
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A very active area of research within the C. elegans community involves the maturation, regulation, and turnover of mRNA.
In this model, a multicompartment PK model is connected to the PD model that is used to describe the maturation, feedback regulation, and turnover of hematopoietic cells and their precursor cells.
Recent studies have also shown that over-expression of Sox9 in hypertrophic chondrocytes results in delayed terminal chondrocyte maturation and cartilage matrix turnover, suggesting a specific role in regulating chondrocyte hypertrophy.
In Rbpjk mutant embryos, haploinsufficiency of Sox9 was able to rescue the delays in onset of chondrocyte hypertrophy, but had little if any impact on delayed progression to terminal chondrocyte maturation and cartilage matrix turnover.
A number of mRNA un-translated regions, particularly at the 3' end, may modulate mRNA maturation, transport, turnover and translation for example and protein turnover may also vary [ 4].
More suggestions(15)
maturation and secretion
maturation and plant
maturation and parturition
maturation and ovulation
maturation and transport
maturation and closure
maturation and acidification
maturation and stability
maturation and fruit
maturation and mortality
maturation and organ
maturation and decline
maturation and survival
maturation and degeneration
maturation and retest
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