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Together, our studies identify SATB1 as a critical regulator of interneuron maturation and terminal differentiation in the mammalian cortex.
In summary, our experiments argue that SATB1 constitutes an activity-dependent molecular switch downstream of Lhx6, which controls the maturation and terminal differentiation of cortical interneurons.
The opposite was observed in perilesional epidermis, consistent with observations that SLURP-2 is important for keratinocyte survival, whereas SLURP-1 for SLURP-1 fore maturation and terminal differentiation.
It is likely that antigen-directed affinity maturation and terminal differentiation of B cells contributing to OCBs occur within perivascular infiltrates and meningeal lymphoidlike follicles in the CNS.
Genes found regulated at early time points appeared to be more involved in generating the neuronal precursor area while genes found highly expressed at E12.5 or later had roles in neuronal maturation and terminal differentiation.
Functional analysis of the dataset through GO-analysis showed that neuronal differentiation was dominantly overrepresented at E12.5, whereas at later stages neuronal maturation and terminal differentiation were the main processes.
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In addition to contributing to food digestion and nutrition and the regulation of metabolism, the gut microbiota is involved in development and terminal maturation of host mucosa, regulation of immune system target recognition and responses, and resistance to colonization and invasion by pathogens.
Since maturation of glycans and terminal sialation occur within the Golgi compartments, this finding suggests either that CD1d molecules can load lipid antigens in the Golgi, or that glycans of CD1d-bound ligands can be modified in the Golgi.
We investigated the early and terminal maturation of monocyte-derived DC (MoDC) in myelodysplastic syndromes (FAB subtypes refractory anemia (MDS-RA) or refractory anemia with ringed sideroblasts (MDS-RARS)).
In contrast to the defects in precursor development in Egr-2 cTg mice, the percentage of DP cells developed into SP and NKT cells and the percentage of immature B cells into mature B cells were increased, suggesting that Egr-2 has a general role in the regulation of progenitors and terminal maturation of lymphocytes, but at restricted stages.
A significant proportion of SC resumed proliferation at PND30, which suggests a defect in the cell cycle exit and terminal maturation of SC.
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maturation and parturition
maturation and ovulation
maturation and transport
maturation and closure
maturation and acidification
maturation and stability
maturation and fruit
maturation and mortality
maturation and organ
maturation and survival
maturation and decline
maturation and degeneration
maturation and retest
maturation and senescence
maturation and storage
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