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Results herein suggest that individual N-glycan location is critical for the stability, regional folding control and secretion of human tyrosinase and explains some tyrosinase gene missense mutations associated with oculocutaneous albinism type I. N-glycosylation plays a pivotal role in glycoprotein maturation and functioning.
The reactive sites formed in a polymer when it is exposed to plasma can be used for grafting various molecules which further modulate the effects of polymer treatment on cell adhesion, growth, phenotypic maturation, and functioning.
During later stages, genes involved in cell replication and stress were downregulated, suggesting maturation and functioning of the new roots.
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We evaluated whether extrinsic or intrinsic factors were responsible for the impaired maturation and function of NK cells in aging and whether impaired maturation correlated with functional hyporesponsiveness.
Estrogen, any of a group of hormones that primarily influence the female reproductive tract in its development, maturation, and function.
Other recent work shows that gut microbes control the maturation and function of microglia, the immune cells that eliminate unwanted synapses in the brain; it is, therefore, tempting to speculate that age-related changes to gut microbe composition might regulate myelination and synaptic pruning in adolescence and could, therefore, contribute to cognitive development.
During both maturation and function, neutrophils are subjected to reorganization of the actin cytoskeleton.
Alveolar macrophages of GM-CSF-deficient mice show abnormalities in morphology, maturation, and function, depending on transcription factor PU.1 [26, 26].
These new mOP cells should significantly benefit in vitro and in vivo studies on OP maturation and function.
Both systems share some actions: BDNF is involved in the maturation and function of 5-HT neurons.
Our work provides a unique resource to study human-specific regulators of islet cell maturation and function.
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