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Adiaphorism, (from Greek adiaphora, "indifferent"), in Christian theology, the opinion that certain doctrines or practices in morals or religion are matters of indifference because they are neither commanded nor forbidden in the Bible.
Hegesias, like Theodorus, doubted the power of reason to procure pleasures and so advised avoidance of pain; much pain of mind could be avoided by regarding such things as poverty and riches, slavery and freedom, death and life as matters of indifference.
When did the "freedom to err" come to seem not merely an unavoidable evil or manifestation of original sin, but an implicit "right," at times celebrated as a sign of individual uniqueness, at times legally protected when such errors fall under the rubric of "matters of indifference"?
Made professor of the New Testament at the University of Jena in 1557, Flacius was soon involved in a new controversy with Melanchthon over adiaphorism, which holds that certain religious doctrines or practices are matters of indifference because they are neither commanded nor forbidden in the Bible.
But many actions, including some heroic actions, are neither obligatory nor prohibited, yet they are hardly matters of indifference.
Urmson's Puzzle—Indifference versus Optionality (Urmson 1958): This seems to describe something quite familiar: optional matters that are nonetheless not matters of indifference.
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In theory, this should have been a matter of indifference.
And whether firms finance themselves with equity or debt is a matter of indifference.
It is a matter of indifference whether it is plausible or not.
But that time is not a matter of indifference to us.
Moreover, it was not and could not be a matter of indifference to those who suffer most.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com