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The results of rGMD and regional gray matter volume are usually similar (Good et al. 2001a).
Also total brain volume and neocortical grey matter volume are significantly reduced in probable Alzheimer's disease subjects.
However, focal increases in grey matter volume are observed in neurodegenerative diseases (Binkofski et al., 2007; Reetz et al., 2009).
These results support that SAD is characterized by aberrant neural activation to affective stimuli in the fear network, while disorder-related alterations in regional gray matter volume are more diffusely distributed over the whole brain.
As increases in total gray matter volume are driven primarily by expanded surface area [ 42], issues of covariance for total brain volume are highly relevant for studies of cortical thickness.
Similar(55)
A limited decrease of white matter volume was observed in 4-month-old SHR.
Insula gray matter volume was negatively correlated with leptin concentration and measures of hunger.
Whether altered gray matter volume is associated with altered functional and structural connectivity in SAD.
Regional voxel-wise comparisons showed that gray matter volume was smallest within frontal and temporal regions of both patient groups.
Grey matter volume was also smaller in DMD and we found no focal differences in grey matter, suggesting an overall deficiency in neuronal cell bodies.
Gray matter volume was found to be lower in the insula, medial orbitofrontal cortex and cerebellum in Obese Prone, as compared to Obese Resistant individuals.
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