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All approved agents follow the same mechanism of binding, but their different chemical structures lead to differences with regard to dosing and dosimetry; pharmacokinetics, including partitioning into grey and white matter structures; and interpretation of visual reads (Eli Lilly 2013; Piramal Imaging 2014; GE Healthcare 2014).
Analysis of the digital 3D renderings and the segmented MRI images indicated that nodules were often due to the printing of "stray" aggregations of misassigned pixels in nearby grey matter structures, and ridges were due to incomplete or "stray" assignment along hippocampal borders (Fig. 2).
Specifically, we hypothesized that measures of diffuse neurodegeneration are more strongly correlated in interconnected grey matter structures and their white matter pathways, than in unconnected structures.
The hypothesis that disruption of thalamocortical development underlies the observed changes would suggest an intimate relationship between gray matter structures and connective white matter tracts.
Neuronal loss was recognized as focal or confluent areas of neuronal drop out in gray matter structures and was often accompanied by reactive gliosis.
Table 2 also shows the Pearson correlation coefficients between neo-cortical grey matter volume and the volumes of the deep grey matter structures, and their corresponding P-values.
Similar(51)
DTI and ASL are methods to non-invasively characterise white matter structure and gray matter function of the brain, respectively [18] [19].
A more complex relationship between white matter structure and executive function was observed.
These results highlight the complexity of the relationships between white matter structure and cognition.
However, the relationship between DTI measures of white matter structure and cognitive function appears not to be this simple.
The effects of group and cognitive variables were modelled, allowing analysis of the relationship between white matter structure and cognitive function across voxels.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com