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Although white matter changes are part of the small vessel disease spectrum, they are discussed separately above.
Second, to analyze if white matter changes are present in the aforementioned areas in individuals with higher cognitive reserve that would result advantageous in terms of migraine chronification.
No white matter changes are seen.
White matter changes are noted in the cerebrum, cerebellum, thalamus, basal ganglia and spinal cord [51].
Periventricular and deep white matter changes are discussed in section 2.3.4.
Arteriolosclerosis and diffuse white matter changes are the hallmark features of both sporadic and hereditary SVDs.
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Age-related grey matter changes were investigated by comparing young and older adults using voxel-based morphometry and voxel-based cortical thickness methods.
It is not yet clear what the relationship of white matter changes is to gray matter changes or subject-specific differences in fMRI activation.
Gray matter changes were observed within the cerebellum as well but were less pronounced.
The grey matter changes were modulated additionally by the presence of co-morbidities and symptom severity.
Frequently the white matter changes were related to previous conditions/insults and included infection, ischaemia, hypoxia, and prematurity.
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