Osteoarthritis, which is characterized by inflammation and degradation of the cartilage matrix, is triggered mainly by excessive joint forces and leads to pathological changes in the joints.
Imaging parameters: TR = 3.3; TE = 1.0; flip angle = 25°; matrix = 256 × 256; which was triggered visually and was acquired in a 15 s breath-hold.
In the same study, it was suggested that pax6 expression was triggered by the alteration of the cell-extracellular matrix and/or cell-cell interactions [ 73, 74].
Overall, these data demonstrated that the alteration of the extracellular matrix may be triggered by alveolar overdistension.
Frequently, this occurs between tumor cells such as breast, cervical, or colon carcinoma cells and can be triggered by matrix detachment (Overholtzer et al., 2007), suggesting that loss of integrin-mediated adhesion may promote cell-in-cell invasion.
Tissue remodeling is triggered by matrix-metalloproteinases (MMPs) and the vascular endothelial growth factor (VEGF), which were found differentially expressed in patients with endometriosis [ 41, 42].
CD44 can be triggered to internalize by extracellular matrix or antibody and to form the transcriptional complex.
They assumed that invasive process is triggered by cancer cells releasing matrix degrading enzymes (MDEs) which modify the ECM by degrading it.
In the latter case, translocation is triggered by a variety of factors, such as extracellular matrix proteins, bile salts or Congo red [ 79].
