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Matrix stiffness and the mechanical tension that results from cellular adhesion to stiff substrates are instrumental in determining the phenotype of many cells in culture [ 75].
Matrix stiffness, and introduction to finite element analysis.
Wen, J. H. et al. Interplay of matrix stiffness and protein tethering in stem cell differentiation.
Targeting matrix stiffness and mechanotransduction could open new avenues for treatment of pancreatic fibrosis (PDAC and chronic pancreatitis) and fibroproliferative diseases in general.
Wang, T., Hamilla, S., Cam, M., Aranda-Espinoza, H. & Mili, S. Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration.
These regions exhibited increased surface roughness, increased microscale PLGA-rich matrix stiffness, and significant change of bulk PCL-rich crystallinity relative to other library regions.
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Moreover, the role of the mechanical microenvironment, including matrix stiffness and shear stress from fluid flow, is known to contribute to cancer progression and drug resistance.
varvec{M}{ddot{varvec{q}}} + varvec{Kq} = {mathbf{0,}} (3)where M, K and F stand for mass matrix, stiffness matrix and force vector, respectively.
By virtue of these functions, the equivalent mass matrix, stiffness matrix and external loading vector of one single coarse element can be determined easily.
Also, non-traditional signals such as matrix stiffness, metabolites and oxidative stress [ 23] are able to activate HSCs.
In a variety of tissues such as the liver, skin, kidney or fat tissue, fibrosis disrupts tissue organization and increases matrix stiffness, affecting normal cell and tissue physiology (Hoffman et al., 2011; Friedman et al., 2013).
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