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Among the highest scoring GO terms were genes associated with the extracellular region, matrix, response to wounding and external stimulus, protease inhibitor activity, and genes associated with acute inflammatory and immune responses (Figure 2D).
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Previous data indicated that, in some cases, chondrocytes can synthesize macromolecules to establish a functional extracellular matrix in response to a matrix-damaging insult or when placed in a three-dimensional environment with inadequate matrix.
On the other hand, the method can be regarded as an improvement to the SOBI-based modal identification method because it uses the Hankel matrix instead of the covariance matrix of response to perform the JAD.
Moreover, TNF- α, TGF- β and IL-1 β can stimulate MSCs to secret high levels of matrix metalloproteinase, which can endow these cells the ability to migrate through extracellular matrix in response to chemokines.
The physiologic response of chondrocytes to maintenance of the matrix and response to injury likely involves signaling from multiple sources including soluble cytokines, mechanical stimulation, and signaling from the extracellular matrix.
It is known that cells proliferate and produce extracellular matrix in response to biochemical and mechanical stimuli.
This bond, the nitrogen analog of a sulfoxide, appears to have arisen at the divergence of sponge and cnidaria, an adaptation of the extracellular matrix in response to mechanical stress in metazoan evolution.
We found that antibody neutralization of TGF-β enhanced the decrease in the tensile strength and tensile modulus of the collagen fascicles of the patellar tendon matrix in response to ex vivo fibroblast infiltration.
The concentration ratios of TCE/ cis-DCE + VC) indicaTCE/ cis-DCE increase in molar CE concentration may result from additional TCE mobilized from the rock matrix in response to the oil injection or due to desorption/diffusion.
Moreover, keratinocytes in the normal wound healing process are regulated to migrate toward the denuded area on the provisional matrix in response to specific cytokines and ECM proteins.
Akt controls a number of metabolic and survival pathway and was recently found to translocate into the mitochondria matrix in response to insulin stimulation.
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