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We conclude that LPA induced cytoskeletal reorganization and cell-matrix traction, which resulted in matrix reorganization and increased tensile properties.
Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Trier, S. M. & Keely, P. J. Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganization.
These results indicate that hMSC might contribute to wound-healing processes by extracellular matrix reorganization and wound contraction but not by differentiation into keratinocytes.
Collectively, these results suggest that strain field anisotropy is an independent regulator of fibroblast cell phenotype, turnover, and matrix reorganization, which may inform normal and pathological remodeling in soft tissues.
The pathologic changes in the liver were associated with markers of hepatic stellate cells (HSCs) activation, matrix reorganization and fibrosis including α-smooth muscle actin, transforming growth factor-β1, PDGF-Rβ, pro-inflammatory cytokines and enhanced expression of tissue inhibitor of metalloproteinase-1 and pro collagen type I.
These data indicate a role for OPN in tissue remodeling in vivo, and suggest physiological functions during matrix reorganization after injury.
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The model did not account for a final phase of the wound healing process, which involves extracellular matrix (ECM) reorganization.
Several genes are components of collagen gene family whose functions are associated with extracellular matrix (ECM) reorganization.
Substantial changes in the extracellular matrix and reorganization of the stroma [ 7, 8] occur in parous breast tissue that have the potential to restrain tumorigenesis [ 9, 10].
Another type of very important signaling molecules of wound healing is growth factors, which activate skin cell proliferation and extracellular matrix components reorganization, by promoting extracellular metalloproteinase production.
Wound repair and regeneration is a highly complex combination of matrix destruction and reorganization.
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