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Robinson BK, Cortes E, Rice AJ, Sarper M, Del Rio, Hernandez A. Quantitative analysis of 3D extracellular matrix remodelling by pancreatic stellate cells.
Robinson, B. K., Cortes, E., Rice, A. J., Sarper, M. & Del Rio Hernandez, A. Quantitative analysis of 3D extracellular matrix remodelling by pancreatic stellate cells.
We find that lovastatin and simvastatin reduce matrix remodelling by fibroblasts and thereby reduce SCC invasion.
We therefore decided to investigate their action on matrix remodelling by CAFs further.
In this work we screen almost 200 compounds for their effect on matrix remodelling by CAFs.
We find that two HMG-CoA reductase inhibitors reduce matrix remodelling by fibroblasts and consequently diminish cancer invasion.
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We focused on the Fb phenotype and collagen deposition, though it is possible that differences in matrix remodeling by MMPs and tissue inhibitors of metalloproteinase (TIMPs) is different in the regions.
Progression of PVD involves extracellular matrix remodeling by elastases and matrix metalloproteinases (MMP), concomitant with proliferation of smooth muscle cells in a growth factor-enriched environment.
For example, osteoclastogenesis itself may be inhibited by physical stimuli [37] but matrix remodeling by mature osteoclasts is enhanced [38].
ITGA3, ITGA5, and the RhoGTPases were required in the force-mediated matrix remodeling, by which the leading stromal fibroblasts were able to generate tracks to support SCC invasion.
In addition, the DDRs regulate extracellular matrix remodeling by controlling matrix metalloproteinase expression and activity.
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