Strikingly, adhesion and interaction with extracellular matrix and surrounding cells are extremely important for integrity and homeostasis maintenance in normal tissues, and alterations in microenvironment and related functions are notoriously associated with cancer transformation and metastasis [ 39].
With the error past information, conveyed by state covariance matrix, a state estimator can predict the state vector one step ahead, thus providing system operators with more information to make control decisions such as security assessment and other related functions.
Among the genes with known or related functions in the mibta52b data set, about 35% belong to the category of 'transcription factor/nuclear' related genes and the remaining genes to other categories, such as 'transport proteins' (25%), 'signaling' (19%), 'structural proteins' (8.6%), 'cell adhesion/matrix' (5.4%), 'hormone activity' (4.3%) and 'cell cycle/apoptosis' (3.2%) (Figure 5E).
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Since it has been well validated that miR-29 functions through the regulation of many different extracellular matrix related genes (van Rooij & Olson, 2012), we confirmed the regulation of a subset of these target genes.
Whereas some of these genes are known to be involved in embryonic developmental processes (e.g. Klf4, Otx2, Smn1, Socs3, Tagln, Tdgf1), our analysis points to others (such as transcription factor Phf21a, extracellular matrix related Lama1 and Cyr61, or endoplasmic reticulum related Sc4mol and Scd2) that have not been previously related to mESC function.
Therefore is the channel matrix related to these MSs.
Using the observed responses to these test signals, a 6 x 6 transfer function matrix relating six piezo-actuator input voltages and the six geophone-sensor output voltages was obtained in the discrete-time domain.
Z is the incidence matrix relating y to u.
Matrix Q f is an incidence matrix relating founder gametes to founder haplotypic classes.
