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Especially, the KEGG pathways oxidative phosphorylation, extracellular matrix receptor interaction and focal adhesion may provide new targets for drug development.
Third, both KEGG terms extracellular matrix receptor interaction and focal adhesion included four common genes (COL5A1, FN1, SPP1, and TNXB) (Figure S2).
Among them, four interconnected pathways ("focal adhesion", "regulation of the actin cytoskeleton", "adherens junction" and "extra cellular matrix receptor interaction") govern growth-related processes and morphogenesis.
The two KEGG pathways extracellular matrix receptor interaction and focal adhesion, with all six genes in these two KEGG categories also included in the large GO Molecular Function category protein binding.
This strategy allowed us to identify the oxidative phosphorylation chain and the extracellular matrix receptor interaction categories, as well as a general category related to cell proliferation and apoptosis, as the only significantly and consistently overrepresented pathways involved in CRC progression.
This strategy, based on testing multiple tools, allowed us to identify the oxidative phosphorylation chain and the extracellular matrix receptor interaction categories, as well as a general category related to cell proliferation and apoptosis, as the only significantly and consistently overrepresented pathways in the three gene lists, which were reported by several enrichment tools.
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For example, extracellular matrix receptor interactions (B), and genes involved in leukocyte transendothelial migration (C).
In GSEA, the most apparent feature of PTC is an upregulation of extracellular activities, like cell communication and adhesion and extracellular matrix receptor interactions.
Predicted target genes of the EV miRNAs included those known to play a role in regulating embryo implantation such as extracellular matrix receptor interactions, adherens and tight junctional proteins and the Jak-STAT signalling and VEGF signalling pathways.
KEGG analysis revealed the coordinated down-regulation of pathways commonly associated with tumorigenesis, such as the extracellular matrix-receptor interaction pathway.
Pathway analysis revealed that genes up-regulated in 'lactating' crop were involved in the proliferation of melanocytes, extracellular matrix-receptor interaction, the adherens junction and the wingless (wnt) signalling pathway.
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