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Chondrocytes in cartilage tissue are embedded in cartilage matrix, raising the question of how chondrocyte-derived chemokines regulate the motility of FLS, which are localized in synovial tissues.
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The fact that the promoting effects were eliminated with collagenase treatment and type I and type III collagen were identified within the adherent fibrillar extracellular matrix raised the possibility that the stimulating factors were collagen-originated.
In the Markov chain model, the second part of the transition matrix raises the sidedness of all cells by one side.
Our initial observation that the MT1-expressing cell lines were overall more motile on a non-polymerised collagen I matrix raised the possibility that MT1 could contribute to invasion by enhancing motility as well as collagen degradation.
The function first computes a pairwise correlation matrix for each set of genes and then calculates an adjacency matrix by raising the matrix to a soft-threshold power.
In particular, the diagonal entries of the matrix raised to the n th power give information about the periodic orbits with period n.
For reaction i this is given by [ M n ] ii, the diagonal value of the matrix raised to the nth power.
The network adjacency matrix is the gene pair-wise correlation matrix raised to the power of 6, chosen based on the scale-free topology criteria [ 77].
Recently, emerging evidence has suggested that caspase-3 is detected in extracellular matrix (ECM), raising the hypothesis that caspase-3 participates in cell cell communications in a paracrine manner.
This co-expression similarity was then transformed into an adjacency matrix by raising the similarity to a certain power based on a scale free topology criterion as described previously [ 16].
We also found that the addition of neutral osmolytes enhances the binding of RNA and oligonucleotides to metal-chelate matrices [9], raising the possibility of water elution of nucleic acids from IMAC adsorbents under-loaded with metal, creating a repulsive surface charge through the unloaded anionic chelators [10].
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