Our results further demonstrate that the expression of matrix proteins characterizing the phenotypical alteration of OA chondrocytes, that is, increased expression of COL1A1, COL3A1, TNC [ 38- 40], did not display a significantly higher expression in OA chondrocytes compared with normal chondrocytes, either after ML culture or in scaffolds.
Repopulation of decellularized lung scaffolds (DLS) is limited due to alterations in the repertoire and ratios of the residual extracellular matrix (ECM) proteins, characterized by e.g., the retention of type I collagen and loss of glycoproteins.
Pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED) are skeletal diseases caused by missense mutations/deletions in the genes encoding important cartilage extracellular matrix proteins (ECM), and are characterized by disproportionate short stature, joint pain and early-onset osteoarthritis.
The obtained graft was characterized for its architecture, extracellular matrix proteins, mechanical and immunological properties.
Liver fibrosis is characterized by the accumulation of extracellular matrix proteins like collagen.
Myocardial fibrosis is a pathological process that is characterized by disrupted regulation of extracellular matrix proteins resulting in permanent scarring of the heart tissue and eventual diastolic heart failure.
This is triggered by the activation of hepatic stellate cells (HSC), which change to a myofibroblast-like phenotype, with a consequent increase in their synthesis of matrix proteins that characterize fibrosis, such as interstitial collagens [ 45].
Scleroderma (SSc) is an autoimmune connective tissue disease characterized by excess production and deposition of extracellular matrix proteins leading to fibrosis of the tissue.
These tumours are characterized by a dense desmoplastic stroma, consisting of extracellular matrix proteins – such as collagens, laminin and fibronectin – together with fibroblasts and immune cells (Adler, 2004).
Systemic sclerosis (SSc) is an autoimmune disorder of unknown origin, characterized by an excessive deposition of collagen and other extracellular matrix proteins on the skin as well as multiple internal organs, alterations in microvasculature, and humoral and cellular abnormalities [ 7].
