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First reports further suggest that these two CCN family members act opposite to each other in regulating extracellular matrix protein expression and reciprocally influence their own expression when over-expressed.
TGF β -3 has also been delivered to adipose derived stem cells (ADSCs) using a baculoviral vector [ 52], in which TGF β-3 expressing cells displayed enhanced collagen II and matrix protein expression improved biomechanical properties.
Dey, N. et al. High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression.
Farina, G. et al. Cartilage oligomeric matrix protein expression in systemic sclerosis reveals heterogeneity of dermal fibroblast responses to transforming growth factor β.
Koga, K. et al. MicroRNA-26a inhibits TGF-beta-induced extracellular matrix protein expression in podocytes by targeting CTGF and is downregulated in diabetic nephropathy.
Selden, C., Khalil, M. & Hodgson, H. Three dimensional culture upregulates extracellular matrix protein expression in human liver cell lines a step towards mimicking the liver in vivo?
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Additionally, miR-124 has also been extensively implicated in glioma pathogenesis [13], [23] although the association with extracellular matrix proteins expression presented in our study is completely novel, necessitating further exploration of their biological relevance.
Moreover, transforming growth factor β molecules are positive regulators of extracellular matrix proteins expression [ 56].
Then pellet was washed twice in 1 ml PBS (1000 x g, 2 min) and processed for assays of inflammatory, catabolic and matrix proteins expressions.
The matrix protein gene expression of CAFs, with proven tumorigenicity in vivo, had a significantly different gene expression profile of matrix proteins compared to patient matched NPFs.
Voisin, M. B., Probstl, D. & Nourshargh, S. Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation.
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