Exact(1)
It is therefore not surprising that germinal matrix pathology is similarly evident in syndromic cases bearing an autism-like phenotype, such as congenital cytomegalovirus infection, antenatal cocaine exposure, extreme prematurity, tuberous sclerosis, and the Ehlers-Danlos syndrome [ 4].
Similar(59)
It was led by the laboratory of Biology and Engineering of Cartilage (Lyon), and carried out in partnership with the laboratory of Extracellular Matrix and Pathology (Caen), Lille Institute of Biology, Symatèse Biomatériaux company (Chaponost) and laboratory of Skin Substitutes (Lyon Hospital).
A study of a number of companies employing some form of matrix reveals nine pathologies to which the matrix design is particularly vulnerable, along with prevention and treatment methods.
A growing body of evidence suggests a critical involvement of fibroblast-like cells in the destruction of extracellular matrix in various pathologies.
The present study demonstrates that low oxygen percentage applied during the differentiation phases of human articular chondrocyte culture enhances cell biosynthetic activity as well as reduces the activity of catabolic enzymes known to play key roles in the breakdown of cartilage matrix during degenerative pathologies.
Markers of cartilage breakdown enable studying the degradation of cartilage matrix in equine joint pathologies.
We postulate enhanced deposition of COMP as one of the common factors altering the supramolecular architecture of collagen matrix in fibrotic skin pathologies.
A clear corollary of this model is that the documented presence of a cytokine during the course of tumour progression is not sufficient in itself to provide an insight into its functional significance, in the absence of complementary data regarding alterations in stroma composition and/or physical organization caused by concurrent, pathology-associated matrix remodelling.
Synovial fibroblasts contribute to RA pathology by releasing matrix-degrading enzymes, including matrix metalloproteinases (MMPs) and cathepsins, which cause cartilage destruction [ 11].
Thus, cadherin-9 might have a role in fibroblast activation, as during development of renal fibrosis activated fibroblasts are regarded as responsible for the massive deposition of extracellular matrix, a hallmark of this pathology.
The cardiac collagen matrix remodels with age or pathology [ 15].
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