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Collagen type I, collagen type III, decorin, tenascin-C are fundamental proteins in the extracellular matrix of tendons.
As soon as possible there is need to widen the knowledge of the effects of HAPs on the main proteins of the extracellular matrix of tendons.
2 5– 7 The extracellular matrix of tendons varies between different tendons and regionally within tendons, and there are changes in tendinopathy or ruptured tendons compared with normal tendons.
The complexity of the extracellular matrix of tendons and its relationship with tenocytes during physiological homeostasis, disease and healing process, attest that is reductive to investigate only the effect of HAPs on collagen type I and III.
The extracellular matrix of tendons is made up of: collagen (65 to 80% dry weight), which is mostly composed of type I collagen and provides the tendons with strength to withstand high loads; elastin (1 to 2%), which insures flexibility and elastic properties; and ground substance, which consists of approximately 60 to 80% water, proteoglycans and glycoproteins.
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50 These enzymes are involved in remodelling the extracellular matrix of tendon and have been linked with tendon rupture.
The extracellular matrix of normal tendons consists of many of structural proteins (collagens) and proteoglycans.
Integra® (Integra LifeSciences, Plainsboro, NJ) is one such product and is a porous matrix of bovine tendon collagen and glycosaminoglycan.
Human tendon explant cultures provide a species-specific model for further investigation of the effects of glucocorticoids on the metabolism of the extracellular matrix of human tendon, and on its mechanical properties.
Such bioactive constructs are often inspired by the native composition, structure, mechanics, and biomolecule environment, offering inspiration toward the development of constructs that mimic the extracellular matrix (ECM) of tendon.
Overall, these data, combined with our previous finding of increased mast cell number in tendon biopsies from patients with patellar tendinopathy, suggest that mast cells have a potential to mediate matrix remodeling of tendon and contribute to tendon degradation.
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