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Tissue engineers may be able to regrow muscle using biomaterial scaffolds, which attempt to mimic the native extracellular matrix of muscle tissue.
However, several dominant mutations in BM patients have no detectable effect on collagen VI assembly and secretion, but compromise protein function in the extracellular matrix of muscle [29].
In spastic hamstrings, increased passive stiffness is caused by increased amounts of collagen in the extracellular matrix of muscle fiber bundles [ 62].
The DAPC provides a link between the cytoskeleton and extracellular matrix of muscle fibers, and maintains the integrity of sarcolemma (muscle membrane) during muscle contraction (Ervasti and Sonnemann, 2008).
An earlier study described the MMP-2 and MMP-9 proteins localization in the entire extracellular matrix of muscle, both around the fibers and capillaries, but MMP-2 was also present inside the skeletal muscle fibers [ 33].
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We previously reported that TGF-β1 promotes the deposition of the α6 chain in the extracellular matrix of normal muscle cells by inducing muscle cell trans-differentiation into a myofibroblast phenotype [19].
We theorized that the changes of the hiatus may affect the ultrastructure of its sarcolemmal plasmic components as well as the extracellular matrix of the muscle.
It remains to be determined, however, whether chronic DR changes SkM strength or the proportions of extracellular matrix to muscle tissue, or alters contractile properties and force per cross-sectional area/muscle quality.
Under the influence of a substratum consisting of cold 0.6 N HCl-decalcified bone matrix, mesenchymal cells of muscle cultured in a series of chemically defined media aggregate and differentiate into chondrocytes which become enclosed in a calcifiable intercellular matrix.
We will focus on the advantages of nanofibrous matrices for muscle regeneration and how investigators combine nanofibres with different types of external stimulation to enhance tissue growth.
Summary: The extracellular protein ADAMTSL2 is a crucial regulator of microfibril composition in the extracellular matrix of bronchial smooth muscle cells and influences bronchial epithelial function.
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