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The matrix of hyaline articular cartilage is composed mainly of proteoglycans (PGs) and type II collagen.
Finally, we tested the ability of anti-GAG antibodies to bind to the extracellular matrix of hyaline cartilage.
WF6 epitope level was variably expressed in the extracellular matrix of hyaline cartilage, which could characterize the releasing pattern of proteoglycans [ 8- 10].
T1rho values have been shown to increase with GAG (PG) content loss of the extracellular matrix of hyaline cartilage, with increases in bulk water and with cartilage softening, while being less dependent on collagen disruption [ 31, 85, 89– 94].
These anti-GAG antibodies of RA patients were not only present in the systemic circulation and in the synovial fluid, but they were also fully capable of binding to the extracellular matrix of hyaline cartilage.
The present study focuses on NAbs that are reactive to glycosaminoglycans (GAGs), important molecular constituents of both cell surface proteoglycans and large and small proteoglycans of the extracellular matrix of hyaline cartilage.
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When compared to age-matched WKY (Additional file 3A), GK rats showed glomerular alterations including basement membrane thickening, matrix accumulation of hyaline, indicating mesangial extracellular matrix expansion, and increased capillary luminal volume suggesting glomerular hypertrophy (Additional files 3B3 and 3C).
Expansion of the extracellular matrix and deposition of hyaline mass in the glomeruli were occasionally seen on day 7 and became obvious and statistically significant from day 14 to day 21.
Using TGFβ1 and BMP2 to induce chondrogenic differentiation in hMSCs in a self-gelling alginate scaffold system, we have recently shown that the differentiated cells upregulate the extracellular matrix (ECM) molecules typical of hyaline cartilage, and downregulate molecules typical of MSC functionality [ 26].
Low-grade chondrosarcoma displays a hyaline cartilage matrix with low cell density, and an abundance of hyaline cartilage matrix, no mitoses and cells with a chondrocyte-like morphology.
Many efforts have been undertaken to improve matrix-based tissue engineering of hyaline cartilage, including manipulation of physical parameters like oxygen supply, improvements of matrix systems or stimulation with growth factors.
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