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The central composite design (CCD) was used to create the matrix of experiments for mapping the chromatographic response surface.
By variation of the solvent, catalyst type and concentration, reaction time, and temperature a matrix of experiments for the DoE method was derived.
A matrix of experiments was build up allowing a polynomial model to express each rheological response according to the dosages of the constituents and some trends about the effect of the various mix constituents and their interactions to be found.
The studied variables were temperature and pH, according to the matrix of experiments showed in Table 1.
These graphs include library sizes, box plots of normalized signals, a correlation matrix of experiments and a two-dimensional Multidimensional Scaling (MDS) plot of the samples to be studied.
We used 155 ENCODE ChIP-seq datasets from 31 DNA binding proteins: 11 HMs and 20 TFs across five cell lines (GM12878, H1-hESC, HeLa-S3, HepG2 and K562), representing the largest complete matrix of experiments of HMs and TFs among tier 1 and tier 2 cell lines.
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Accordingly experiments were designed and Table 3 shows the design matrix of the experiments for three different particle sizes.
For this analysis, we constructed a meta-data matrix of microarray experiments from the NASC repository (Nottingham Arabidospsis Stock Center, [ 44]) covering all available hormone and hormone inhibitor treatment experiments (including auxin, abscisic acid, ethylene, cytokinin, brassinosteroids, giberellic acid and jasmonic acid).
The robustness of this method was evaluated using the Plackett Burman fractional factorial experimental design with a matrix of 15 experiments and the statistical treatment proposed by Youden and Steinner.
Besides, a robustness test was performed using the Plackett Burman fractional factorial experimental design using a matrix of 15 experiments for seven factors (internal parameters) with a statistical treatment suggested by Youden and Steinner.
However, the complicated, heterogeneous nature of blood and the diverse range of chemical forms and routes by which individuals may be exposed to Pu give rise to a matrix of potential experiments that are difficult to design, collate, comprehend and rationalise.
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