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Another mechanism to take advantage of matrix mechanical properties therapeutically is in targeting death of cells via alterations in matrix rigidity.
This work provides a microscale characterization of fibroblast-derived matrix mechanical properties.
The machinability of particulate metal matrix composites (PMMC) is influenced by the matrix mechanical properties as well as size, distribution and volume fracture of reinforcement particles.
These findings suggest that simply modulating the matrix mechanical properties of a given wound dressing biomaterial deposited at the wound site could regulate the progression of wound healing.
Wound dressing biomaterials are increasingly being designed to incorporate bioactive molecules to promote healing, but the impact of matrix mechanical properties on the biology of resident cells orchestrating skin repair and regeneration remains to be fully understood.
It was further shown to be dependent on the hydrogel matrix mechanical properties and accompanied by the upregulation of genes involved in epithelial-mesenchymal transition (EMT), metabolism and angiogenesis.
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To our knowledge, no research attempt has been reported that examined stretch-activated mechanotransduction on neurites in dissociated neurons through a specific adhesion mechanism while providing control over the cell-matrix mechanical properties.
This model converts extracellular-matrix mechanical properties to biochemical signals via adhesion, and integrates intracellular signaling cascades associated with cytoskeleton dynamics.
In this work the influence of weak interface between particles and matrix on mechanical properties of metal matrix – ceramic reinforced composites is studied.
Mechanical characterization shows that the presence of 6% of alumina particles in the matrix improved Mechanical properties than other combination of alumina with matrix material.
Boehmite nanoparticles show great potential in improving the matrix dominated mechanical properties of fiber reinforced polymers.
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