Sentence examples for matrix genes such from inspiring English sources

Semi-quantitative real-time gene expression analysis of characteristic chondrocytic matrix genes, such as cartilage link protein, cartilage oligomeric matrix protein, aggrecan, and types I, II, and IX collagen, confirmed the induction of the chondrocytic phenotype in high-density culture upon stimulation with BMP2 and transforming growth factor-β3 (TGFβ3).

Previously, we found that the SPARC (secreted protein, acidic, and rich in cysteine) gene is involved in the regulation of extracellular matrix genes such as COL1A2, COL3A1, CTGF and TIMP3, and this regulation is associated with activation of the TGF-β pathway [29], [30].

These included late angiogenic, morphogenic and extracellular matrix genes such as ANGPTL4, COL1A1, GP2, GPR57, LAMB3, PCDHB9 and PTGER3.

In addition, long treatments do not induce Sox9 expression but upregulate atypical cartilage matrix genes such as COL1A1 and COL10A1.

One of its actions is to activate specific enhancer elements in cartilage matrix genes such as collagen type II and aggrecan [ 39, 40].

Asporin inhibits TGFβ-mediated expression of cartilage matrix genes such as collagen type II and aggrecan, and inhibits accumulation of proteoglycan [ 39].

DMECM was also the main component to regulate cell behaviors, which promoted meniscus cells expressing extracellular matrix related genes such as COL I, COL II, SOX9 and AGG.

The cluster 2 contained the transcripts most significantly influenced by vitamin D deficiency, which consisted of 19 genes including NPAS2 and the disproportionately large representation of cartilage extracellular matrix (ECM) genes such as type II, type X and type IX collagen alpha chains, hyaluronan-proteoglycan link protein and dermatan sulfate proteoglycan 3 (Figure 2B).

In particular, down-regulation of extracellular matrix (ECM) genes such as col1a1, osteocalcin, osteonectin and decorin, indicated that maturation and mineralization of osteoblasts were restrained.

The influence of genetic variants of different matrix metalloproteinase genes, such as MMP-9 [ 47, 48] or MMP-3 [ 49], on clinical outcome of CAD was described in previous studies.

The livers of FOLFOX-treated animals also showed changes in matrix remodelling genes such as TGFβ (P<0.01), MMP2 (P<0.001), TIMP1 (P<0.001) and Pro-Collagen I (P<0.05) which was exacerbated in the presence of tumour.