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This paper describes the first successful use of modified thermosensitive gelatin-based nanocomposites as a suitable matrix for localized and sustained gene delivery to the urothelium via the intravesical route.
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Although the precise coordination of the molecular events behind degenerative tissue remodeling remains unclear, demonstrating that MMP-2 is critical for localized matrix turnover by AF cells serves as an important step toward mechanistic understanding of DDD.
On the other hand, the release of dexamethasone from ulvan particles embedded within the PDLLA matrix revealed that the designed systems can be potentially suitable for localized drug delivery.
Collagen matrices can be used as non-viral biocompatible gene carriers for localized implantable gene therapy.
Matrix coils consisting of multiple coil elements appear to offer a high flexibility in generating customized encoding fields and are particularly promising for localized high resolution imaging applications.
Loc genes b-numbers for localized genes.
This provides a semisolid gel-like matrix into which cells extend invadopodia [ 47, 48]; these processes contribute to cell movement and also matrix degradation via localized proteolysis [ 47].
For example, CEACAMs (Carcinoembryonic antigen-related cell adhesion molecule 4, 7, 21) are matrix molecules localized at the apical glycocalyx of normal colonic epithelium.
DICS was also employed for localizing (inter-trial) phase-coherent sources in theta (4 6 Hz) by means of cross-spectral density matrices in relation to particular reference signals (see Gross et al. 2004; Kessler et al. 2006).
Most of the mitochondrial dehydrin-like proteins from cauliflower inflorescences were found probably matrix localized; nevertheless, a putative candidate (65 kDa) for a membrane-associated one was also proposed.
Figure 6 shows the process for localizing target one.
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