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Levett, P. A. et al. A biomimetic extracellular matrix for cartilage tissue engineering centered on photocurable gelatin, hyaluronic acid and chondroitin sulfate.
Acellular cartilage can provide a native extracellular matrix for cartilage engineering.
These features indicate that CH-GA/PA hydrogels are promising as an artificial extracellular matrix for cartilage tissue engineering.
We prepare an elastic macroporous gelatin/chondoitin-6-sulfate/hyaluronan (GCH) cryogel scaffold mimic the composition of cartilage extracellular matrix for cartilage tissue engineering.
These scaffolds promote the self-aggregation of mesenchymal stem cells (MSCs) and, with timely release of the bioactive ingredients, induce the chondrogenic differentiation of MSCs and produce matrix for cartilage repair.
HDM_derm seems to be a suitable matrix for cartilage regeneration, because it has been shown by the present study to maintain cellular viability and differentiation, and to retain structure and bioactivity, particularly TGF-β1 that might counteract catabolic IL-1β effects, whose levels have been found to correlate with the severity of cartilage damage in vivo.
Similar(54)
Here, fused poly(lactide-co-glycolide) microsphere scaffolds were seeded with human umbilical cord mesenchymal stromal cells to demonstrate the feasibility of utilizing these matrices for cartilage regeneration.
Injectable hydrogels based on hyaluronic acid (HA) and poly ethylene glycol) (PEG) were designed as biodegradable matrices for cartilage tissue engineering.
Hydrogels are suitable matrices for cartilage tissue engineering on account of their resemblance to native extracellular matrix of articular cartilage and also considering its ease of application, they can be delivered to the defect site in a minimally invasive manner.
These results demonstrate the correlation between lineage commitment and the changes in cell shape, cell matrix interaction, and cell cell adhesion during chondrogenic differentiation which is regulated by polyurethane phase morphology, and thus, represent hydrophilic polyurethanes as promising synthetic matrices for cartilage regeneration.
Benders, K. E. M. et al. Extracellular matrix scaffolds for cartilage and bone regeneration.
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