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Nanosized hydroxyapatite is a material that is commonly used as a matrix for bone tissue engineering.
Calcium phosphates (CaP) based materials are widely recognized as the most suitable matrix for bone tissue engineering.
Surface mineralization is an effective method to produce calcium phosphate apatite coating on the surface of bone tissue scaffold which could create an osteophilic environment similar to the natural extracellular matrix for bone cells.
Importantly, in vivo studies showed that this synergism was able to generate significantly increased new bone in an ectopic mouse model, suggesting that PCL/HA-3D scaffolds act as a favorable synthetic extracellular matrix for bone regeneration.
Given the relevance of integrin signaling for cellular homeostasis, we developed an injectable, bioactive peptide-based nanofiber matrix that presents an integrin-binding epitope derived from fibronectin, and evaluated its feasibility as a supportive artificial matrix for bone marrow-derived pro-angiogenic cells (BMPACs) used as a therapy in ischemic tissue repair.
The sealing zone is a cell-matrix adhesion machinery that creates an isolated space between the cell and the matrix for bone resorption.
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We demonstrated that radio-frequency plasma surface functionalized electrospun poly(ɛ-caprolactone) (PCL) fibres provide a suitable matrix for bone-marrow-derived mesenchymal stem cell (MSC) cardiac implantation.
One of the major limitations found in the use of nanocomposites based on synthetic hydroxyapatite and polymeric matrix for bone-tissue regeneration lies in the poor interfacial adhesion between the inorganic filler and the polymer matrix.
This study opens the possibility to engineer, through biomineralization process, advanced hybrid matrices for bone regeneration.
An understanding of this process could also guide the development of matrices for bone tissue engineering.
The ability to successfully cryopreserve mineralized tissue engineered matrices for bone may offer an unlimited and readily available source of bone-like materials for orthopaedic applications.
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