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Findings ascribed to tubulointerstitial fibrosis included matrix expansion with tubular distortion and basement membranes thickening.
Light microscopy showed a glomerular mesangial matrix expansion with segmental mesangial cell proliferation.
All renal biopsies revealed diffuse mesangial matrix expansion with nodule formation and foci of mesangiolysis.
Mesangial matrix expansion was assessed in PAS sections with a 0 4 scale (0 = normal, 1 = mild mesangial matrix expansion, 2 = moderate matrix expansion with patent capillaries, 3 = severe matrix expansion with segmental capillary loop consolidation, 4 = severe matrix expansion with global capillary loop consolidation).
Kidney histology demonstrated modest matrix expansion with focal segmental sclerosis associated with vascular hyalinosis and extensive and diffuse tubular damage; in the tubular lumina large and occlusive RBC casts were evident.
MPGN is characterized by mesangial hypercellularity and matrix expansion, with thickening of glomerular capillaries (with the formation of double contours), interposition of leukocytes and mesangial cells, and synthesis of new GBM resulting in lobular accentuation of glomerular tufts.
Similar(53)
Under electron microscopy, the CTG is associated with deposition of flocculent or fibrillary material; mesangial cellular proliferation with matrix expansion; multilamination or multilayering of the capillary basement membrane.
Although IgAN is considered a glomerular disease, the damage occurring in the glomerulus with matrix expansion and sclerosis ultimately leads to tubular damage.
Eight weeks after STZ injection, the diabetic rats demonstrated mesangial matrix expansion in glomeruli compared with normal control rats.
The histologic features of IgAN show an increase in mesangial proliferation with matrix expansion; other glomerular lesions may include focal necrosis, segmental sclerosis, and crescent formations [ 12].
The reduction of mesangial matrix expansion and fibrosis significantly differed with vehicle KK-Ay mice.
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