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Matrix effects are very important when developing a method, since they might affect reproducibility and accuracy [34, 35, 40 43].
Since no matrix effects are observed, quantification can readily be carried out by external calibration with ultrapure water standards.
Matrix effects are defined as the unexpected suppression or enhancement of the analyte response due to the presence of other compounds in the sample.
Although the addition of isotopically-labeled internal standards to compensate for matrix effects are often considered a lengthy and labor intensive method [28, 56].
Risks of variations related to potential matrix effects are therefore reduced, as well as probable variations related to the digestion steps.
Matrix effects are also compared with ESI on a refined selection of 19 pharmaceutical and biological compounds in 4 matrices commonly encountered in bioanalysis.
Similar(30)
Matrix effects were thoroughly studied.
Extraction efficiency and matrix effects were determined.
Matrix effects were observed for the C14 MCA only.
The data for matrix effects were in the range of ±15%, indicating no significant matrix effects.
Extraction efficiency and matrix effects were evaluated using standard addition method.
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